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dr. P.M.J. (Paco) Welsing

dr. P.M.J. (Paco) Welsing

Associate Professor
dr. P.M.J. (Paco) Welsing
  • Rheumatology & Clinical Immunology

Biography

Biography

I am a clinical Epidemiologist and HTA researcher. My research focuses on the optimal application of health interventions in daily clinical practice with a focus on rheumatic and immunologic diseases, mainly Rheumatoid Arthritis (RA) and Osteoarthritis (OA). More stratified approaches to treatment and the measurement of these treatment effects have been studied in different project, acting as project member/methodologist or (WP) lead. Examples are the CTMM TRACER project focussing on the clinical and health-economic evaluation of personalized approached to diagnosis and treatment of RA, the IMI APPROACH project focussing on exploring phenotypes of osteoarthritis for stratified treatment approaches, the IMI GetReal project focusing on the use of ‘Real World’ data in drug evaluation, specifically focussing on pragmatic trial design and using data from routine practice in trials, the multicenter PATIO trial evaluating a prediction based decision aid tool for tapering biological drugs in RA, the nationwide RCT and cohort study, GODIVA, regarding the (cost-)effectiveness and optimal patient group for joint distraction in young patients with severe knee OA and the EU STRATA-FIT project focussing on difficult-to-treat RA and the development of a stratified treatment approach and decision aid using real world. As the full effects of a treatment strategy when applied in clinical practice are of interest my research naturally includes modelling the clinical effectiveness as well as cost-effectiveness on the long term. I enjoy applying/adapting state-of the art statistical and Machine Learning methods in an innovative and creative way to clinical research questions also working as a methodologist consultant for our division.

Research Output (186)

Development and validation of a machine learning-supported strategy of patient selection for osteoarthritis clinical trials:the IMI-APPROACH study

Widera Paweł, Welsing Paco M.J., Danso Samuel O., Peelen Sjaak, Kloppenburg Margreet, Loef Marieke, Marijnissen Anne C., van Helvoort Eefje M., Blanco Francisco J., Magalhães Joana, Berenbaum Francis, Haugen Ida K., Bay-Jensen Anne Christine, Mobasheri Ali, Ladel Christoph, Loughlin John, Lafeber Floris P.J.G., Lalande Agnès, Larkin Jonathan, Weinans Harrie, Bacardit Jaume Dec 2023, In: Osteoarthritis and Cartilage Open. 5

Clinical Validation of a Primary Antibody Deficiency Screening Algorithm for Primary Care

Messelink Marianne A., Welsing Paco M.J., Devercelli Giovanna, Marsden Jan Willem N., Leavis Helen L. Nov 2023, In: Journal of Clinical Immunology. 43 , p. 2022-2032 11 p.

Endoscopic ultrasonography-guided gastroenterostomy versus surgical gastrojejunostomy for palliation of malignant gastric outlet obstruction (ENDURO):study protocol for a randomized controlled trial

Kastelijn Janine B, van de Pavert Yorick L, Besselink Marc G, Fockens Paul, Voermans Rogier P, van Wanrooij Roy L J, de Wijkerslooth Thomas R, Curvers Wouter L, de Hingh Ignace H J T, Bruno Marco J, Koerkamp Bas Groot, Patijn Gijs A, Poen Alexander C, van Hooft Jeanin E, Inderson Akin, Mieog J Sven D, Poley Jan-Werner, Bijlsma Alderina, Lips Daan J, Venneman Niels G, Verdonk Robert C, van Dullemen Hendrik M, Hoogwater Frederik J H, Frederix Geert W J, Molenaar I Quintus, Welsing Paco M J, Moons Leon M G, van Santvoort Hjalmar C, Vleggaar Frank P, 25 Sep 2023, In: Trials. 24 14 p.

Identifying multivariate disease trajectories and potential phenotypes of early knee osteoarthritis in the CHECK cohort

Altamirano Sara, Jansen Mylène P., Oberski Daniel L., Eijkemans Marinus J.C., Mastbergen Simon C., Lafeber Floris P.J.G., van Spil Willem E., Welsing Paco M.J. 14 Jul 2023, In: PLoS ONE. 18 13 p.

Development of a primary care screening algorithm for the early detection of patients at risk of primary antibody deficiency

Messelink Marianne A, Berbers Roos M, van Montfrans Joris M, Ellerbroek Pauline M, Gladiator André, Welsing Paco M J, Leavis Helen 27 May 2023, In: Allergy, asthma, and clinical immunology: official journal of the Canadian Society of Allergy and Clinical Immunology. 19 15 p.

Concomitant prednisone may alleviate methotrexate side-effects in rheumatoid arthritis patients

van der Leeuw Matthijs S., Tekstra Janneke, van Laar Jacob M., Welsing Paco M.J. 17 May 2023, In: BMC Rheumatology. 7 6 p.

Machine-learning predicted and actual 2-year structural progression in the IMI-APPROACH cohort

Jansen Mylène P., Wirth Wolfgang, Bacardit Jaume, van Helvoort Eefje M., Marijnissen Anne C.A., Kloppenburg Margreet, Blanco Francisco J., Haugen Ida K., Berenbaum Francis, Ladel Cristoph H., Loef Marieke, Lafeber Floris P.J.G., Welsing Paco M., Mastbergen Simon C., Roemer Frank W. 1 May 2023, In: Quantitative Imaging in Medicine and Surgery. 13 , p. 3298-3306 9 p.

Healthcare Costs and Health-Related Quality of Life in Older Multimorbid Patients After Hospitalization

Salari Paola, Henrard Séverine, O’Mahony Cian, Welsing Paco, Bhadhuri Arjun, Jungo Katharina Tabea, Beck Thomas, O’Mahony Denis, Byrne Stephen, Spinewine Anne, Knol Wilma, Rodondi Nicolas, Schwenkglenks Matthias 10 Jan 2023, In: Health services insights. 16 12 p.

Co-sensitization between legumes is frequently seen, but variable and not always clinically relevant

Smits Mark, Verhoeckx Kitty, Knulst André, Welsing Paco, de Jong Aard, Gaspari Marco, Ehlers Anna, Verhoeff Paulien, Houben Geert, Le Thuy My 2023, In: Frontiers in allergy. 4

A European-Japanese study on peach allergy:IgE to Pru p 7 associates with severity

Kallen E. J.J., Revers A., Fernández-Rivas M., Asero R., Ballmer-Weber B., Barreales L., Belohlavkova S., de Blay F., Clausen M., Dubakiene R., Ebisawa M., Fernández-Perez C., Fritsche P., Fukutomi Y., Gislason D., Hoffmann-Sommergruber K., Jedrzejczak-Czechowicz M., Knulst A. C., Kowalski M. L., Kralimarkova T., Lidholm J., Metzler C., Mills E. N.C., Papadopoulos N. G., Popov T. A., Purohit A., Reig I., Seneviratne S. L., Sinaniotis A., Takei M., Versteeg S. A., Vassilopoulou A. E., Vieths S., Welsing P. M.J., Zwinderman A. H., Le T. M., Van Ree R. 2023, In: Allergy: European Journal of Allergy and Clinical Immunology. 78 , p. 2497-2509 13 p.

All research output

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