dr. S.J. (Bas) Vastert
dr. S.J. (Bas) Vastert
- Center for Translational Immunology (CTI) Research
- Rheumatology Research 1
- Immunology
Research Programs
Biography
Biography
Bas is a pediatric rheumatologist in the “EULAR center of excellence in rheumatology" Wilhelmina Children’s Hospital Utrecht. Besides being an esteemed clinician in the field of Pediatric Rheumatology, he has developed into a translational researcher, with a PhD on mechanisms of disease and therapy in severe JIA in 2013. From 2015, he has been starting a translational research group together with Jorg van Loosdregt, molecular biologist. They currently supervise 5 PhD students, 1 post-doc and 2 technicians together, within the Center of Translational Immunology in Utrecht (v Loosdregt-Vastert group). Their labgroup aims to translate cutting edge science into clinical benefit for patients and their research focusses on systemic JIA and on development of novel treatment strategies for JIA. Bas is currently leading a multi-center prospective trial implementing a biomarker driven stop-strategy for rIL-1RA therapy in systemic JIA in the Netherlands (the ESTIS trial).
In addition, as a designated Young Investigator, Bas is the Dutch lead for all translational laboratory studies within UCAN CAN DU (major infrastructural research project 2017-2021 in Canada and the Netherlands).
Key words: Translational research in childhood arthritis, biology of systemic JIA, (regulation of) auto-inflammation, regulation of autoimmune inflammation, epigenetics.
Side Activities
- member editoreal board van Pediatric Rheumatology Online Journal
- associate editor Rheumatology
Fellowship and Awards
- 2007: Young investigator Meeting, Pediatric rheumatology European Society: Award for best basic abstract .
- 2014: Wilhelmina Research Fund (co-applicant), € 150 000 : Dissecting the complex role of S100-proteins in systemic juvenile idiopathic arthritis.
- 2015: ZonMW Rational Pharmacotherapy grant, € 340 000 : Biomarker guided treatment and stop strategy for rIL-1RA therapy in systemic JIA.
- 2016-2019: Wilhelmina Kinderziekenhuis Fonds, Rosenberg foundation / Vrienden WKZ (€340 000): Modulation of Treg in JIA by Nicotinamide. Principal Investigator, no overlap.
- 2016-2021: ZonMW grant, Rational Pharmacotherapy for implementation of biomarker guided tapering strategy of rIL-1RA in systemic JIA (€340 000 + €190 000 contribution Sobi). Principal Investigator, clinical trial, no overlap.
- 2017-2021: UCAN CAN DU: (8,0 mln Can$). Canada – Netherlands Personalized Medicine Network in Childhood Arthritis and Rheumatic diseases. Young Investigator, NL lead for laboratory studies within UCAN CAN DU. (PI: R. Yeung, NM Wulffraat, co-PI JF Swart, S. Benseler).
Research Output (158)
Shakoory Bita, Geerlinks Ashley, Wilejto Marta, Kernan Kate, Hines Melissa, Romano Micol, Piskin David, Ravelli Angelo, Sinha Rashmi, Aletaha Daniel, Allen Carl, Bassiri Hamid, Behrens Edward M., Carcillo Joseph, Carl Linda, Chatham Winn, Cohen Jeffrey I., Cron Randy Q., Drewniak Erik, Grom Alexei A., Henderson Lauren A., Horne Annacarin, Jordan Michael B., Nichols Kim E., Schulert Grant, Vastert Sebastiaan, Demirkaya Erkan, Goldbach-Mansky Raphaela, De Benedetti Fabrizio, Marsh Rebecca A., Canna Scott W. 1 Oct 2023, In: Annals of the rheumatic diseases. 82 , p. 1271-1285 15 p.
Hamad Saied Mohamad, van der Griend Laura, van Straalen Joeri W, Wulffraat Nico M, Vastert Sebastiaan, Jansen Marc H A 7 Aug 2023, In: Pediatric rheumatology online journal. 21 , p. 1-10
van Til Janine A, Kip Michelle M A, Schatorjé Ellen J H, Currie Gillian, Twilt Marinka, Benseler Susanne M, Swart Joost F, Vastert Sebastiaan J, Wulffraat Nico, Yeung Rae S M, Groothuis-Oudshoorn C G M Karin, Warta Sanne, Marshall Deborah A, IJzerman Maarten J, 11 Jul 2023, In: Pediatric rheumatology online journal. 21 , p. 1-10
van der Velden Fabian J.S., Lim Emma, Gills Lily, Broadey Jasmin, Hayes Louise, Roberts Eve, Courtney Jack, Ball Joanne, Herberg Jethro, Galassini Rachel, Emonts Marieke, Levin Michael, Cunnington Aubrey, Kaforou Myrsini, Wright Victoria, Bellos Evangelos, Broderick Claire, Channon-Wells Samuel, Cooray Samantha, De Tisham, D’Souza Giselle, Elorrieta Leire Estramiana, Estrada-Rivadeneyra Diego, Habgood-Coote Dominic, Hamilton Shea, Jackson Heather, Kavanagh James, Marjaneh Mahdi Moradi, Nichols Samuel, Nijman Ruud, Patel Harsita, Pennisi Ivana, Powell Oliver, Reid Ruth, Shah Priyen, Vito Ortensia, Whittaker Elizabeth, Wilson Clare, Womersley Rebecca, Abdulla Amina, Darnell Sarah, Nagelkerke Sietse, van der Flier Michiel, Tissing Wim J.E., Vastert Sebastiaan J., Vijlbrief Daniel C., Bont Louis J., Wolfs Tom F.W., Beudeker Coco R., Hulsmann Sanne C., 5 Jul 2023, In: BMC Medical Ethics. 24 , p. 1-11
van Vroonhoven Ellen C.N., Picavet Lucas W., Scholman Rianne C., van den Dungen Noortje A.M., Mokry Michal, Evers Anouk, Lebbink Robert J., Calis Jorg J.A., Vastert Sebastiaan J., van Loosdregt Jorg Jul 2023, In: Biology. 12 11 p.
Ho Antonia, Orton Richard, Tayler Rachel, Asamaphan Patawee, Herder Vanessa, Davis Chris, Tong Lily, Smollett Katherine, Manali Maria, Allan Jay, Rawlik Konrad, McDonald Sarah E., Vink Elen, Pollock Louisa, Gannon Louise, Evans Clair, McMenamin Jim, Roy Kirsty, Marsh Kimberly, Divala Titus, Holden Matthew T.G., Lockhart Michael, Yirrell David, Currie Sandra, O’Leary Maureen, Henderson David, Shepherd Samantha J., Jackson Celia, Gunson Rory, MacLean Alasdair, McInnes Neil, Bradley-Stewart Amanda, Battle Richard, Hollenbach Jill A., Henderson Paul, Odam Miranda, Chikowore Primrose, Oosthuyzen Wilna, van den Berg J. M.Merlijn, Nagelkerke Sietse, van der Flier Michiel, Tissing Wim J.E., Wösten-van Asperen Roelie M., Vastert Sebastiaan J., Vijlbrief Daniel C., Bont Louis J., Wolfs Tom F.W., Beudeker Coco R., Tempel Dennie, van Keulen Danielle, , 30 May 2023, In: Nature. 617 , p. 555-563 9 p.
Currie Gillian R, Groothuis-Oudshoorn Catherina G M, Twilt Marinka, Kip Michelle M A, IJzerman Maarten J, Benseler Susanne M, Swart Joost F, Vastert Sebastiaan J, Wulffraat Nico M, Yeung Rae, Marshall Deborah A 19 May 2023, In: Clinical Rheumatology. 42 , p. 2173-2180 8 p.
Morfopoulou Sofia, Buddle Sarah, Torres Montaguth Oscar Enrique, Atkinson Laura, Guerra-Assunção José Afonso, Moradi Marjaneh Mahdi, Zennezini Chiozzi Riccardo, Storey Nathaniel, Campos Luis, Hutchinson J. Ciaran, Counsell John R., Pollara Gabriele, Roy Sunando, Venturini Cristina, Antinao Diaz Juan F., Siam Ala’a, Tappouni Luke J., Asgarian Zeinab, Ng Joanne, Hanlon Killian S., Lennon Alexander, McArdle Andrew, Czap Agata, Rosenheim Joshua, Andrade Catarina, Anderson Glenn, Lee Jack C.D., Williams Rachel, Williams Charlotte A., Tutill Helena, Nagelkerke Sietse, van der Flier Michiel, Tissing Wim J.E., Wösten-van Asperen Roelie M., Vastert Sebastiaan J., Vijlbrief Daniel C., Bont Louis J., Wolfs Tom F.W., Beudeker Coco R., Tempel Dennie, van Keulen Danielle, de Groot Ronald, van der Flier Michiel, van Aerde Koen, Heidema J., Miedema C. J., Jongerius Ilse, van den Berg J. M., Schonenberg D., Zandstra Judith, , , 18 May 2023, In: Nature. 617 , p. 564-573 10 p.
Ohm Milou, van Straalen Joeri W, Zijlstra Marieke, de Joode-Smink Gerrie, Jasmijn Sellies Anne, Swart Joost F, Vastert Sebastiaan J, van Montfrans Joris M, Bartels Marije, van Royen-Kerkhof Annet, Wildenbeest Joanne G, Lindemans Caroline A, Wolters Victorien, Wennink Roos A W, de Boer Joke H, Knol Mirjam J, Heijstek Marloes W, Sanders Elisabeth A M, Verduyn-Lunel Frans M, Berbers Guy A M, Wulffraat Nico M, Jansen Marc H A 15 May 2023, In: Vaccine. 41 , p. 3782-3789 8 p.
Nijhuis L, Swart J F, Prakken B J, V Loosdregt J, Vastert S J 19 Apr 2023, In: Clinical and Experimental Immunology. 213 , p. 276-287 12 p.