prof. dr. L. Meyaard
prof. dr. L. Meyaard
- Center for Translational Immunology (CTI)
Research Programs
Biography
Biography
Linde Meyaard obtained her PhD in 1995 (cum laude) at Sanquin in Amsterdam studying mechanism of immune dysfunction in HIV infection. In 1996 she entered the immune inhibitory receptor field as a post-doc at DNAX Research Institute in California. She identified a novel inhibitory immune receptor, LAIR-1, and continued her work on this receptor in as a fellow of the Royal Academy of Sciences (KNAW) in the UMC Utrecht.
Since 2000 she leads her own research group embedded in the Center Translational Immunology, supported by multiple grants such as the NWO Vidi and Vici. Meyaard was the first to identify collagens and collagen-like proteins as the natural ligands for LAIR-1. She then extended her research towards other inhibitory receptors and studies these inhibitory receptors in the context of cancer, inflammation and immunopathology of viral infections.
In 2016-2017 she spent a year as visiting scientist at Yale Medical School in the lab of Professor Ruslan Medzhitov. In 2018 she became a principle investigator at Oncode Institite for cancer research. Since september 2018 she is department head of the Center for Translational Immunology at the UMC Utrecht.
In her current work, Meyaard continues to ask fundamental immunological questions regarding inhibitory receptors to develop novel concepts that can be translated to clinic application. She proposed that inhibitory receptors can be grouped in functional categories with different purposes. Recently, her lab identified SIRL-1 as a receptor recognizing endogenous and microbial molecular patterns, introducing the concept of inhibitory pattern recognition receptors. Furthermore, they discovered that inflammation can rewire inhibitory signaling and influence the functional outcome. Together with clinicians, Meyaard translates these concepts to cancer and inflammation. By collaborating with multiple biotech and pharmaceutical companies she aims for clinical application of her work.
Side Activities
Investigator at Oncode Institute
Member of review panel ENW Open Program
Member of the ESCUlab review committee of the European Lead Factory
Collaborative research agreements with NextCure, NGM Biopharmaceuticals, Boehringer Ingelheim
Fellowship and Awards
1999-2001 Fellow of the Royal Dutch Academy of Science (KNAW)
2001 NWO Vidi
2002 NWO Aspasia
2014 NWO Vici
Research Output (121)
von Richthofen Helen J., Meyaard Linde May 2023, In: European Journal of Immunology. 53 10 p.
von Richthofen Helen J., Hafkamp Florianne M.J., van Haperen Anouk, de Jong Esther C., Meyaard Linde Apr 2023, In: PLoS ONE. 18
von Richthofen Helen J., Westerlaken Geertje H.A., Gollnast Doron, Besteman Sjanna, Delemarre Eveline M., Rodenburg Karlijn, Moerer Petra, Stapels Daphne A.C., Andiappan Anand K., Rötzschke Olaf, Nierkens Stefan, Leavis Helen L., Bont Louis J., Rooijakkers Suzan H.M., Meyaard Linde 15 Feb 2023, In: Journal of immunology (Baltimore, Md. : 1950). 210 , p. 389-397 9 p.
Geerdink Ruben J., Pascoal Ramos Maria Inês, van den Hoogen Luuk L., Radstake Timothy R.D.J., Shibayama Shiro, Shibuya Akira, Bont Louis, Meyaard Linde Dec 2022, In: Immunity, inflammation and disease. 10 , p. 1-9
Besteman Sjanna B, Phung Emily, Raeven Henriette H M, Amatngalim Gimano D, Rumpret Matevž, Crabtree Juliet, Schepp Rutger M, Rodenburg Lisa W, Siemonsma Susanna G, Verleur Nile, van Slooten Rianne, Duran Karen, van Haaften Gijs, Beekman Jeffrey M, Chang Lauren A, Meyaard Linde, van der Bruggen Tjomme, Berbers Guy A M, Derksen Nicole, Nierkens Stefan, Morabito Kaitlyn M, Ruckwardt Tracy J, Kurt-Jones Evelyn A, Golenbock Douglas, Graham Barney S, Bont Louis J 16 Apr 2022, In: The Journal of infectious diseases. 226 , p. 258-269 12 p.
van der Vlist Michiel, Raoof Ramin, Willemen Hanneke L.D.M., Prado Judith, Versteeg Sabine, Martin Gil Christian, Vos Martijn, Lokhorst Roeland E., Pasterkamp R. Jeroen, Kojima Toshiyuki, Karasuyama Hajime, Khoury-Hanold William, Meyaard Linde, Eijkelkamp Niels 14 Dec 2021, In: Neuron. 110 , p. 613-626
Rumpret Matevž, von Richthofen Helen J, Peperzak Victor, Meyaard Linde 14 Dec 2021, In: Journal of Experimental Medicine. 219
van der Vlist Michiel, Pascoal Ramos M Inês , van den Hoogen Lucas L, Hiddingh Sanne, Timmerman Laura M, de Hond Titus A P, Kaan Ellen D, van der Kroef Maarten, Lebbink Robert Jan, Peters Florence M A, Khoury-Hanold William, Fritsch-Stork Ruth, Radstake Timothy R D J, Meyaard Linde 12 Oct 2021, In: Science Signaling [E]. 14 , p. 1-11
Vijver Saskia V., Singh Akashdip, Mommers-Elshof Eline T.A.M., Meeldijk Jan, Copeland Ronald, Boon Louis, Langermann Sol, Flies Dallas, Meyaard Linde, Ramos M. Inês Pascoal 7 Oct 2021, In: Frontiers in Immunology. 12 , p. 1-13
Rumpret Matevž, von Richthofen Helen J., van der Linden Maarten, Westerlaken Geertje H.A., Talavera Ormeño Cami, van Strijp Jos A.G., Landau Meytal, Ovaa Huib, van Sorge Nina M., Meyaard Linde Oct 2021, In: FASEB Journal. 35 , p. 1-19 19 p.