prof. dr. J. Klumperman
prof. dr. J. Klumperman
- Cell Biology
Research Programs
Biography
Biography
Since 2001 Judith Klumperman is professor of Cell Biology and since 2008 chair of the Department of Cell Biology at the UMC Utrecht. She is also head of the Cell Microscopy Core of the UMC Utrecht, which is widely recognized as one of the best expertise centers in the world for immuno-electron microscopy. On a yearly basis the UMC Utrechts trains and assist over 40 scientists from the Netherlands and 15-20 international guests.She is often asked for expert microscopy advise and participate(d) in a large number of international collaborations.
Her research focus on understanding the molecular basis of human diseases, with an emphasis on diseases of the endo-lysosomal system. Diseases specifically addressed in my work are: Lysosomal storage disorders (Pompe disease; Mucolipidosis II/I-Cell disease) – Alzheimer disease – Hermansky Pudlak Syndrome (pigmentation bleeding disorder) - Cancer – virus and bacterial infections – ARC syndrome –Microvillar inclusion Disease. In addition, her work has elucidated fundamental concepts of endosome and lysosome biogenesis, of which the most recent finding is a novel pathway for the delivery of lysosomal membrane proteins to the lysosomes.
Side Activities
Regular (>10) member or chair of Appointment Advisory Committee’s (Benoemings Advies Commissies) for new professors (Utrecht, Nijmegen, Wageningen and Groningen University
Regular (>20) member of chair of thesis assessment committee’s (Universities of Utrecht, Leiden, Rotterdam, Amsterdam, Nijmegen, Leuven (Belgium), Copenhagen (Denmark)).
ESFRI initiative EuroBioImaging. 2010-2014: Steering Committee (member). 2009-2014: WP4: Coordinator for Correlative Light Electron Microscopy.
Utrecht Graduate School Institute of Biomembranes, (interim project leader, Board Member, Chair) 2000-2010
Netherlands Society for Microscopy (NVvM) Board member, Vice president 2001-2007
Member project management team NL-BioImaging-AM, the Dutch Research Infrastructure for Advanced Microscopy. 2001-2007
Royal Dutch Academy of Arts and Sciences (KNAW). Financing Biomedical Research and Council for Medical Sciences and Royal Dutch Academy of Arts and Sciences (KNAW). Chair exploratory committee ‘Tissue Engineering’ 2002-2011
committee NWO medium-sized investment grants and Big Investments 2001-2015
University Utrecht delegation to improve contact with Chinese universities 2006
Regional committee Asia, University of Utrecht 2006-2010
ZON-MW (Medical Research Netherlands – Medical Sciences) -committee medium-sized (<9k€) investment grants. Member and Vice-chair 2005-2009
Utrecht PhD program ‘Biomembranes’. 2004-2006: Board member. 2007-2010: Chair. 2010 – present: Board member
Member committee ‘Internationalisering II’. UMC Utrecht 2008-2011
Chair committee Electron microscopy University Utrecht 2011
Coordinator CLEM workpackage ESFRI infrastructure EuroBioimaging 2009-2015
Member user committees STW (foundation for technical sciences) in projects of Meijering (Erasmus MC), Gerritsen (UU), Giepmans (UMC Groningen) and Koster (Leiden UMC) 2012-2018
Member international review panel Cell Biology and Biophysics Unit European Molecular Biology Laboratory (EMBL), Heidelberg, Germany 2013
Chair ad hoc committee scientific integrity, installed by B. vd Zwaan, rector University Utrecht 2013-2014
vice-National Contact person (NCP) for the Netherlands in EuroBioImaging 2009-2015
Member project management team NL-BioImaging-AM, the Dutch Research Infrastructure for Advanced Microscopy. 2001-1015
NL-BioImaging-AM. Dutch Roadmap initiative for Research Infrastructure for Advanced Microscopy. 2011-present: Vice-chair of the Project Management Team
Dutch Technology Centre (DTL).2011-present: Member of the Core group
Associate editor: Molecular Biology of the Cell. Editorial boards: Traffic, Histochemistry and Cell Biology, Biology of the Cell, PeerJ. Section editor: Current Opinion in Cell Biology. Member of FACULTY F1000
Cell Microscopy Centre (CMC), UMC Utrecht, Chair (2009-2018)
Steering Committee EM Square, Utrecht University (2015 - present)
Netherlands Electron Microscopy Infrastructure (NEMI) Chair Executive Board (2015 - present)
Center for Molecular Medicine (CMM) UMC Utrecht, member management team (2018 - present)
Editorships
Traffic, Histochemistry and Cell Biology, Biology of the Cell, Current Opinion in Cell Biology (Section editor of the Membranes and organelles issue in 2004 and 2021), Molecular Biology of the Cell (associate editor till 2018), PeerJ (Open access journal of The Royal Society)
August 2021: Guest editor Current Opinion in Cell Biology
Reviewer: Cell, Nature, Journal of Cell Biology, EMBO Journal, Nature Cell Biology, Nature Communications, Cell Reports, Molecular Biology of the Cell, Journal of Cell Science, Traffic, Histochemistry & Cell Biology.
Grant reviewer: Dutch Society for Scientific research (NWO), Wellcome Trust (UK), Medical Research Council (UK), Telethon (Italy), KNAW, Koningin Wilhelmina Fonds (KWF), EMBO
Fellowship and Awards
2007: 20th Foundation lecture, Center for Cell and Molecular Biology, Hyderabad, India.
2004: VICI Award (1.25M€) from the Netherlands Organisation for Scientific Research.
1998: UMC Utrecht award: Attraction and maintenance of female talent.
Research Output (172)
van der Krift Felix, Zijlmans Dick W., Shukla Rhythm, Javed Ali, Koukos Panagiotis I., Schwarz Laura L.E., Timmermans-Sprang Elpetra P.M., Maas Peter E.M., Gahtory Digvijay, van den Nieuwboer Maurits, Mol Jan A., Strous Ger J., Bonvin Alexandre M.J.J., van der Stelt Mario, Veldhuizen Edwin J.A., Weingarth Markus, Vermeulen Michiel, Klumperman Judith, Maurice Madelon M. Nov 2023, In: Life Science Alliance. 6 , p. 1-19 19 p.
de Heus Cecilia, Fermie Job, Loginov Sergey, Gerritsen Hans C, Klumperman Judith, Liv Nalan 22 Jul 2023, In: Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada. 29 , p. 1188 1 p.
Liv Nalan, Fermie Job, Ten Brink Corlinda B M, de Heus Cecilia, Klumperman Judith 2023, In: Methods in Cell Biology. 177 , p. 301-326 26 p.
van der Velden Lieke M, Maas Peter, van Amersfoort Miranda, Timmermans-Sprang Elpetra P M, Mensinga Anneloes, van der Vaart Elisabeth, Malergue Fabrice, Viëtor Henk, Derksen Patrick W B, Klumperman Judith, van Agthoven Andreas, Egan David A, Mol Jan A, Strous Ger J 28 Jul 2022, In: Frontiers in Endocrinology. 13
Fermie Job, de Jager Leanne, Foster Helen E, Veenendaal Tineke, de Heus Cecilia, van Dijk Suzanne, Ten Brink Corlinda, Oorschot Viola, Yang Lin, Li Wei, Müller Wally H, Howes Stuart, Carter Andrew P, Förster Friedrich, Posthuma George, Gerritsen Hans C, Klumperman Judith, Liv Nalan 23 May 2022, In: Cell reports methods. 2 , p. 1-22
Loginov Sergey V, Fermie Job, Fokkema Jantina, Agronskaia Alexandra V, De Heus Cilia, Blab Gerhard A, Klumperman Judith, Gerritsen Hans C, Liv Nalan 11 Apr 2022, In: Frontiers in Cell and Developmental Biology. 10 , p. 1-17
De Mazière Ann, van der Beek Jan, van Dijk Suzanne, de Heus Cecilia, Reggiori Fulvio, Koike Masato, Klumperman Judith 7 Apr 2022, In: Autophagy. 18 , p. 3004-3022 19 p.
Tavares Sandra, Liv Nalan, Pasolli Milena, Opdam Mark, Rätze Max A K, Saornil Manuel, Sluimer Lilian M, Hengeveld Rutger C C, van Es Robert, van Werkhoven Erik, Vos Harmjan, Rehmann Holger, Burgering Boudewijn M T, Oosterkamp Hendrika M, Lens Susanne M A, Klumperman Judith, Linn Sabine C, Derksen Patrick W B 5 Apr 2022, In: Cell Reports. 39 , p. 1-24
Zhang Min, Chiozzi Riccardo Zenezini, Skerrett-Byrne David A, Veenendaal Tineke, Klumperman Judith, Heck Albert J R, Nixon Brett, Helms J Bernd, Gadella Bart M, Bromfield Elizabeth G 18 Feb 2022, In: Frontiers in Cell and Developmental Biology. 10 , p. 1-18
van der Beek Jan, de Heus Cecilia, Liv Nalan, Klumperman Judith 3 Jan 2022, In: The Journal of cell biology. 221 , p. 1-28