prof. dr. P.W.B. Derksen
prof. dr. P.W.B. Derksen
- Department of Pathology
Research Programs
Biography
Biography
Patrick Derksen (1970) obtained his PhD at the department of Pathology, Academic Medical Center, Amsterdam, The Netherlands. Following his graduation in 2003, he moved to the Netherlands Cancer Institute to study the consequences inactivation of cell-cell adhesion in breast cancer development and progression. Here he developed two mouse models for human invasive lobular carcinoma (ILC), by conditional and mammary-specific knockout of E-cadherin and p53. In 2005 he was awarded an independent researcher grant from the Dutch organization for scientific research (NWO-VENI) in 2005. In 2007, he joined the Medical Oncology department as an independent researcher and head of the UMCU Mouse Cancer Clinic. He received a NWO-VIDI award in 2008. In 2010 his position was tenured as an Associate Professor at the Department of Pathology.
His group is aiming at combining expertise on adhesion molecules, cell signaling and clinically relevant mouse models to study the downstream effectors of the adherens junction complex that propel breast cancer development and progression.
Research in the Derksen laboratory is currently sponsored by grants from NWO, KWF, H2020, STW and Breast Cancer Now.
Side Activities
Chair European Lobular Breast Cancer Consortium (ELBCC)
Chair COST Action #19138 LOBSTERPOT
Scientific Advisory Board Member of the Lobular Breast Cancer Alliance (LBCA)
co-investigator POSEIDON-2-Lobular Clinical intervention trial
Fellowship and Awards
NWO-VENI 916.56.135. (2006)
AICR 07-585. (2007)
Pink Ribbon Award (2008)
NWO-VIDI 016.096.318. (2009)
KWF-UU 2011-5230 (2011)
Stichting Vrienden UMC Utrecht (2011)
KWF UU 2013-5801 (2013)
KWF-UU 2014-7201 (2015)
Research Output (55)
Ter Steege Eline J, Doornbos Loes W, Haughton Peter D, van Diest Paul J, Hilkens John, Derksen Patrick W B, Bakker Elvira R M 1 Aug 2023, In: Cancer Letters. 568 , p. 1-10
Gallego-Paez Lina M, Edwards William J S, Chanduri Manasa, Guo Yanyu, Koorman Thijs, Lee Chieh-Yu, Grexa Nina, Derksen Patrick, Yan Jie, Schwartz Martin A, Mauer Jan, Goult Benjamin Thomas 1 May 2023, In: The Journal of cell biology. 222
Sluimer Lilian M., Bullock Esme, Rätze Max A.K., Enserink Lotte, Overbeeke Celine, Hornsveld Marten, Brunton Valerie G., Derksen Patrick W.B., Tavares Sandra Feb 2023, In: Journal of cell science. 136
Ter Steege Eline J, Sijnesael Thijmen, Enserink Lotte, Klarenbeek Sjoerd, Haakma Wisse E, Bakker Elvira R M, Derksen Patrick W B Jan 2023, In: Neoplasia. 35
Sijnesael Thijmen, Richard François, Rätze Max Ak, Koorman Thijs, Bassey-Archibong Blessing, Rohof Christa, Daniel Juliet, Desmedt Christine, Derksen Patrick Wb 2023, In: Journal of Pathology. 261 , p. 477-489 13 p.
Kechagia Zanetta, Sáez Pablo, Gómez-González Manuel, Canales Brenda, Viswanadha Srivatsava, Zamarbide Martín, Andreu Ion, Koorman Thijs, Beedle Amy E M, Elosegui-Artola Alberto, Derksen Patrick W B, Trepat Xavier, Arroyo Marino, Roca-Cusachs Pere 2023, In: Nature materials. 22 , p. 1409-1420 12 p.
Ter Steege Eline J, Boer Mandy, Timmer Nikki C, Ammerlaan Carola Me, Song Ji-Ying, Derksen Patrick Wb, Hilkens John, Bakker Elvira Rm Nov 2022, In: Journal of Pathology. 258 , p. 289-299 11 p.
van der Velden Lieke M, Maas Peter, van Amersfoort Miranda, Timmermans-Sprang Elpetra P M, Mensinga Anneloes, van der Vaart Elisabeth, Malergue Fabrice, Viëtor Henk, Derksen Patrick W B, Klumperman Judith, van Agthoven Andreas, Egan David A, Mol Jan A, Strous Ger J 28 Jul 2022, In: Frontiers in Endocrinology. 13
Rätze Max A K, Koorman Thijs, Sijnesael Thijmen, Bassey-Archibong Blessing, van de Ven Robert, Enserink Lotte, Visser Daan, Jaksani Sridevi, Viciano Ignacio, Bakker Elvira R M, Richard François, Tutt Andrew, O'Leary Lynda, Fitzpatrick Amanda, Roca-Cusachs Pere, van Diest Paul J, Desmedt Christine, Daniel Juliet M, Isacke Clare M, Derksen Patrick W B 24 May 2022, In: Oncogene. 41 , p. 3507-3509 3 p.
Van Baelen K, Geukens T, Maetens M, Tjan-Heijnen V, Lord C J, Linn S, Bidard F-C, Richard F, Yang W W, Steele R E, Pettitt S J, Van Ongeval C, De Schepper M, Isnaldi E, Nevelsteen I, Smeets A, Punie K, Voorwerk L, Wildiers H, Floris G, Vincent-Salomon A, Derksen P W B, Neven P, Senkus E, Sawyer E, Kok M, Desmedt C 20 May 2022, In: Annals of oncology : official journal of the European Society for Medical Oncology. 33 , p. 769-785 17 p.