prof. dr. O.L. Cremer
prof. dr. O.L. Cremer
- Intensive Care Medicine
Research Programs
Biography
Biography
Olaf Cremer (1971) was trained as an anesthesiologist, intensivist and clinical epidemiologist. He has worked as a consultant in the department of intensive care medicine of the UMCU since 2007. Dr. Cremer has designed and co-developed the patient data management system that is currently in use. His detailed knowledge of the system and computer programming skills allow him to explore this clinical database as a rich source of information for several research projects within the division.
Prof. Cremer obtained his PhD degree in 2005 with a doctoral thesis on goal-directed management of patients with severe traumatic brain injury. His thesis included both experimental clinical studies focused on cerebrovascular pathophysiology, as well as large cohort studies focused on patient outcomes. Since 2010 he has been studying the clinical epidemiology of infections in the ICU and/or the postoperative setting. He is one of the PI's of the MARS consortium, a multicentre collaboration aimed at developing new molecular technologies for early diagnosis and risk stratification of sepsis. More recently he initiated the PLUTO project, a longitudinal biorepository of patients undergoing elective surgery in the UMCU. The main focus areas of his research group include:
1 - diagnostic uncertainty in early detection of sepsis
2 - attributable morbidity and mortality of (nosocomial) sepsis and acute inflammation
3 - decision support for diagnosis and treatment of sepsis
Cremer has been mentoring 18 PhD students to date.
Side Activities
Committees and advisory boards
2023 - Chair of the Science & Innovation Committee, Dutch Society of Intensive Care (NVIC)
2023 - ISAB member for the International Clinical Research Center (ICRC), St. Anne's Univeristy Hospital, Brno, Czech Republic
2023 - Advisory board member for Research and Innovation, Dutch Association of Medical Specialists (FMS)
2021 - GlaxoSmithKline (otilimab drug development) - money paid to UMCU
2021 - Parexel (adrenomed ENCOURAGE program) - money paid to UMCU
Industry collaborations
2015-2019 - ImmuneXpress Inc. (Seattle, WA) – Unrestricted research grant (105K)
2021-2022 - Abionic SA (Epalinges, Switzerland) – Unrestricted research grant (60K)
2022-2024 - Prolira BV (Utrecht, Netherlands) - In kind contributions to research (50K)
2023-2026 - Presymptom Health Ltd. (Porton Down, UK) - In kind and in cash contributions to research
Speaker fees
2022 - Committee for European Education in Anaesthesiology
Memberships
ESICM
NVIC
Research Output (236)
de Mul Nikki, Verlaan Diede, Ruurda Jelle P, van Grevenstein Wilhelmina M U, Hagendoorn Jeroen, de Borst Gert-Jan, Vriens Menno R, de Bree Remco, Zweemer Ronald P, Vogely Charles, Haitsma Mulier Jelle L G, Vernooij Lisette M, Reitsma Johannes B, de Zoete Marcel R, Top Janetta, Kluijtmans Jan A J, Hoefer Imo E, Noordzij Peter, Rettig Thijs, Marsman Marije, de Smet Anne Marie G A, Derde Lennie, van Waes Judith, Rijsdijk Mienke, Schellekens Willem Jan M, Bonten Marc J M, Slooter Arjen J C, Cremer Olaf L 19 Apr 2023, In: BMJ Open. 13 16 p.
Smoor Rosa M, van Dongen Eric P A, Verwijmeren Lisa, Emmelot-Vonk Mariëlle H, Vernooij Lisette M, Cremer Olaf L, Noordzij Peter G 6 Apr 2023, In: Journal of the American Geriatrics Society. 71 , p. 2520-2529 10 p.
Michels Erik H A, Butler Joe M, Reijnders Tom D Y, Cremer Olaf L, Scicluna Brendon P, Uhel Fabrice, Peters-Sengers Hessel, Schultz Marcus J, Knight Julian C, van Vught Lonneke A, van der Poll Tom, 13 Dec 2022, In: Critical care (London, England). 26
Dam Tariq A, Roggeveen Luca F, van Diggelen Fuda, Fleuren Lucas M, Jagesar Ameet R, Otten Martijn, de Vries Heder J, Gommers Diederik, Cremer Olaf L, Bosman Rob J, Rigter Sander, Wils Evert-Jan, Frenzel Tim, Dongelmans Dave A, de Jong Remko, Peters Marco A A, Kamps Marlijn J A, Ramnarain Dharmanand, Nowitzky Ralph, Nooteboom Fleur G C A, de Ruijter Wouter, Urlings-Strop Louise C, Smit Ellen G M, Mehagnoul-Schipper D Jannet, Dormans Tom, de Jager Cornelis P C, Hendriks Stefaan H A, Achterberg Sefanja, Oostdijk Evelien, Reidinga Auke C, Festen-Spanjer Barbara, Brunnekreef Gert B, Cornet Alexander D, van den Tempel Walter, Boelens Age D, Koetsier Peter, Lens Judith, Faber Harald J, Karakus A, Entjes Robert, de Jong Paul, Rettig Thijs C D, Arbous Sesmu, Vonk Sebastiaan J J, Machado Tomas, Herter Willem E, de Grooth Harm-Jan, Thoral Patrick J, Girbes Armand R J, Hoogendoorn Mark, 20 Oct 2022, In: Annals of Intensive Care. 12
Ong David S Y, Chong Ga-Lai M, Chemaly Roy F, Cremer Olaf L Oct 2022, In: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 28 , p. 1335-1344 10 p.
Vagliano Iacopo, Schut Martijn C, Abu-Hanna Ameen, Dongelmans Dave A, de Lange Dylan W, Gommers Diederik, Cremer Olaf L, Bosman Rob J, Rigter Sander, Wils Evert-Jan, Frenzel Tim, de Jong Remko, Peters Marco A A, Kamps Marlijn J A, Ramnarain Dharmanand, Nowitzky Ralph, Nooteboom Fleur G C A, de Ruijter Wouter, Urlings-Strop Louise C, Smit Ellen G M, Mehagnoul-Schipper D Jannet, Dormans Tom, de Jager Cornelis P C, Hendriks Stefaan H A, Achterberg Sefanja, Oostdijk Evelien, Reidinga Auke C, Festen-Spanjer Barbara, Brunnekreef Gert B, Cornet Alexander D, van den Tempel Walter, Boelens Age D, Koetsier Peter, Lens Judith, Faber Harald J, Karakus A, Entjes Robert, de Jong Paul, Rettig Thijs C D, Reuland M C, Arbous Sesmu, Fleuren Lucas M, Dam Tariq A, Thoral Patrick J, Lalisang Robbert C A, Tonutti Michele, de Bruin Daan P, Elbers Paul W G, de Keizer Nicolette F, 22 Sep 2022, In: International Journal of Medical Informatics. 167
Exterkate Lotte, van Tienhoven Arne J, Haaksma Mark E, Heldeweg Micah L A, Fleuren Lucas, Thoral Patrick, Dam Tariq A, Heunks Leo M A, Gommers Diederik, Cremer Olaf L, Bosman Rob J, Rigter Sander, Wils Evert-Jan, Frenzel Tim, Vlaar Alexander P, Dongelmans Dave A, de Jong Remko, Peters Marco, Kamps Marlijn J A, Ramnarain Dharmanand, Nowitzky Ralph, Nooteboom Fleur G C A, de Ruijter Wouter, Urlings-Strop Louise C, Smit Ellen G M, Mehagnoul-Schipper D Jannet, Dormans Tom, de Jager Cornelis P C, Hendriks Stefaan H A, Achterberg Sefanja, Oostdijk Evelien, Reidinga Auke C, Festen-Spanjer Barbara, Brunnekreef Gert B, Cornet Alexander D, van den Tempel Walter, Boelens Age D, Koetsier Peter, Lens Judith, Faber Harald J, Karakus A, Entjes Robert, de Jong Paul, Rettig Thijs C D, Arbous Sesmu, Vonk Bas, Machado Tomas, Girbes Armand R J, Sieswerda Elske, Elbers Paul W G, Tuinman Pieter R 8 Sep 2022, In: Shock (Augusta, Ga.). 58 , p. 358-365 8 p.
Klanderman Robert B, van Mourik Nielsvan, Eggermont Dorus, Peters Anna-Linda, Tuinman Pieter R, Bosman Rob, Endeman Henrik, Cremer Olaf L, Arbous Sesmu M, Vlaar Alexander P J Sep 2022, In: Transfusion. 62 , p. 1752-1762 11 p.
Noordermeer Tessa, Schutgens Roger E G, Visser Chantal, Rademaker Emma, de Maat Moniek P M, Jansen A J Gerard, Limper Maarten, Cremer Olaf L, Kruip Marieke J H A, Endeman Henrik, Maas Coen, de Laat Bas, Urbanus Rolf T, Aug 2022, In: Research and practice in thrombosis and haemostasis. 6
Alshalani Abdulrahman, Uhel Fabrice, Cremer Olaf L, Schultz Marcus J, de Vooght Karen M K, van Bruggen Robin, Acker Jason P, Juffermans Nicole P 14 Jun 2022, In: Blood Advances. 6 , p. 3260-3267 8 p.