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prof. dr. P.J. Coffer

prof. dr. P.J. Coffer

Full Professor

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Research Output (185)

Pyruvate metabolism controls chromatin remodeling during CD4+ T cell activation

Mocholi Enric, Russo Laura, Gopal Keshav, Ramstead Andrew G, Hochrein Sophia M, Vos Harmjan R, Geeven Geert, Adegoke Adeolu O, Hoekstra Anna, van Es Robert M, Pittol Jose Ramos, Vastert Sebastian, Rutter Jared, Radstake Timothy, van Loosdregt Jorg, Berkers Celia, Mokry Michal, Anderson Colin C, O'Connell Ryan M, Vaeth Martin, Ussher John, Burgering Boudewijn M T, Coffer Paul J 1 Jun 2023, In: Cell Reports. 42 , p. 1-24

Chemotherapy-induced intestinal injury promotes Galectin-9-driven modulation of T cell function

Jansen Suze A, Cutilli Alessandro, de Koning Coco, van Hoesel Marliek, Sierra Leire Saiz, Nierkens Stefan, Mokry Michal, Nieuwenhuis Edward E S, Hanash Alan M, Mocholi Enric, Coffer Paul J, Lindemans Caroline A 30 Apr 2023,

Epigenetic changes in inflammatory arthritis monocytes contribute to disease and can be targeted by JAK inhibition

Peeters Janneke G C, Boltjes Arjan, Scholman Rianne C, Vervoort Stephin J, Coffer Paul J, Mokry Michal, Vastert Sebastiaan J, van Wijk Femke, van Loosdregt Jorg 10 Jan 2023, In: Rheumatology (Oxford, England). 62 , p. 2887-2897 11 p.

Regulation of a progenitor gene program by SOX4 is essential for mammary tumor proliferation

Roukens M Guy, Frederiks Cynthia L, Seinstra Danielle, Braccioli Luca, Khalil Antoine A, Pals Cornelieke, De Neck Simon, Bornes Laura, Beerling Evelyne, Mokry Michal, de Bruin Alain, Westendorp Bart, van Rheenen Jacco, Coffer Paul J 2021, In: Oncogene. 40 , p. 6343-6353 11 p.

C/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition

Lourenço Ana Rita, Roukens M. Guy, Seinstra Danielle, Frederiks Cynthia L., Pals Cornelieke E., Vervoort Stephin J., Margarido Andreia S., van Rheenen Jacco, Coffer Paul J. 7 Feb 2020, In: Nature Communications. 11 , p. 1-18

Transcriptomic and Epigenomic Profiling of Histone Deacetylase Inhibitor Treatment Reveals Distinct Gene Regulation Profiles Leading to Impaired Neutrophil Development

Govers Anita M A P, Wiggers Caroline R M, van Boxtel Ruben, Mokry Michal, Nieuwenhuis Edward E S, Creyghton Menno P, Bartels Marije, Coffer Paul J Aug 2019, In: HemaSphere. 3

Epigenetic drug screen identifies the histone deacetylase inhibitor NSC3852 as a potential novel drug for the treatment of pediatric acute myeloid leukemia

Wiggers Caroline R M, Govers Anita M A P, Lelieveld Daphne, Egan David A, Zwaan C Michel, Sonneveld Edwin, Coffer Paul J, Bartels Marije 1 May 2019, In: Pediatric Blood & Cancer. 66

Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells

Fleskens Veerle, Minutti Carlos M., Wu Xingmei, Wei Ping, Pals Cornelieke E.G.M., McCrae James, Hemmers Saskia, Groenewold Vincent, Vos Harm Jan, Rudensky Alexander, Pan Fan, Li Huabin, Zaiss Dietmar M., Coffer Paul J. 26 Mar 2019, In: Cell Reports. 26 , p. 3600-3612.e6

Global transcriptional analysis identifies a novel role for SOX4 in tumor-induced angiogenesis

Vervoort Stephin J., de Jong Olivier G., Guy Roukens M., Frederiks Cynthia L., Vermeulen Jeroen F., Lourenço Ana Rita, Bella Laura, Vidakovic Ana Tufegdzic, Sandoval José L., Moelans Cathy, van Amersfoort Miranda, Dallman Margaret J., Bruna Alejandra, Caldas Carlos, Nieuwenhuis Edward, van der Wall Elsken, Derksen Patrick, van Diest Paul, Verhaar Marianne C., Lam Eric W.F., Mokry Michal, Coffer Paul J. 3 Dec 2018, In: eLife. 7

SOX4 inhibits oligodendrocyte differentiation of embryonic neural stem cells in vitro by inducing Hes5 expression

Braccioli Luca, Vervoort Stephin J., Puma Gianmarco, Nijboer Cora H., Coffer Paul J. 1 Dec 2018, In: Stem Cell Research. 33 , p. 110-119 10 p.

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