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prof. dr. ir. J. Malda Full Professor

  • Department of Orthopaedics
  • Department of Orthopaedics

J. Malda

Contact

Research Programs

Biography

  1. Our research group focuses on biofabrication and biomaterials design, in particular for the regeneration of (osteo) chondral defects. We are developing novel biofabriaction strategies, as well and “bioinks” for 3D printing. These hydrogel-based “inks” are both designed to drive specific differentiation of the embedded and/or endogenous cells, as well as to allow fabrication with high shape fidelity in order to generate constructs that are a blueprint of the real tissue. In addition, we are adopting bioreactor technology to mature the generated tissue constructs. Finally, approaches towards the translation of the constructs in veterinary (equine) and human clinics are pursued, including its use as an in vitro platform for testing. 

    Areas of interest 
    - Joint regeneration 
    - Biofabrication 

    - Biomaterial development

    - Bioreactors

    - Extracellular matrix-derived scaffolds 

    - Nutrient limitation 

Side Activities

  • International Society for Biofabrication (ISBF), President

    International Cartilage Repair Society (ICRS), General Board member, Fellow member and Chair of Basic Science Committee

  • Professor of Biofabrication in Translational Regenerative Medicine (0.3FTE), Department of Equine Sciences, Utrecht University

    Former President of the International Society for Biofabrication (ISBF)

    Co-chair of the international Conference on Biofabrication 2015

Fellowship and Awards

Research Output (134)

Organs by design:Can bioprinting meet self-organization?

Martin Ivan, Malda Jos, Rivron Nicolas C. 1 okt 2019, In: Current Opinion in Organ Transplantation. 24 , p. 562-567 6 p.

Rethinking articular cartilage regeneration based on a 250-year-old statement

Malda Jos, Groll Jürgen, van Weeren P. René okt 2019, In: Nature Reviews Rheumatology. 15 , p. 571-572 2 p.

A Versatile Biosynthetic Hydrogel Platform for Engineering of Tissue Analogues

Klotz Barbara J, Oosterhoff Loes A, Utomo Lizette, Lim Khoon S, Vallmajo-Martin Queralt, Clevers Hans, Woodfield Tim B F, Rosenberg Antoine J W P, Malda Jos, Ehrbar Martin, Spee Bart, Gawlitta Debby 12 aug 2019, In: Advanced Healthcare Materials. 8

Effects of body mass on microstructural features of the osteochondral unit:A comparative analysis of 37 mammalian species

Mancini I A D, Rieppo L, Pouran B, Afara I O, Braganca F M Serra, van Rijen M H P, Kik M, Weinans H, Toyras J, van Weeren P R, Malda J 3 jul 2019, In: Bone. 127 , p. 664-673 10 p.

T2* and quantitative susceptibility mapping in an equine model of post-traumatic osteoarthritis:assessment of mechanical and structural properties of articular cartilage

Nykänen Olli, Sarin Jaakko K, Ketola Juuso H, Leskinen Henri, Te Moller Nikae C R, Tiitu Virpi, Mancini Irina A D, Visser Jetze, Brommer Harold, René van Weeren P, Malda Jos, Töyräs Juha, Nissi Mikko J 2 jul 2019, In: Osteoarthritis and Cartilage. 27 , p. 1481-1490 10 p.

Bi-layered micro-fibre reinforced hydrogels for articular cartilage regeneration

Castilho Miguel, Mouser Vivian, Chen Mike, Malda Jos, Ito Keita 22 jun 2019, In: Acta Biomaterialia. 95 , p. 297-306 10 p.

Mogelijkheden van 3D-printen in de geneeskunde:5 jaar later

Visser Jetze, Melchels Ferry P W, Weinans Harrie, Kruyt Moyo C, Malda Jos 5 jun 2019, In: Nederlands Tijdschrift voor Geneeskunde. 163

Arthroscopic Determination of Cartilage Proteoglycan Content and Collagen Network Structure with Near-Infrared Spectroscopy

Sarin Jaakko K, Nykänen Olli, Tiitu Virpi, Mancini Irina A D, Brommer Harold, Visser Jetze, Malda Jos, van Weeren P René, Afara Isaac O, Töyräs Juha 6 mei 2019, In: Annals of Biomedical Engineering. 47 , p. 1815-1826 12 p.

Visible Light Cross-Linking of Gelatin Hydrogels Offers an Enhanced Cell Microenvironment with Improved Light Penetration Depth

Lim Khoon S, Klotz BJ, Lindberg Gabriella C J, Melchels Ferry P W, Hooper Gary J, Malda Jos, Gawlitta Debby, Woodfield Tim B F 26 apr 2019, In: Macromolecular Bioscience. 19 14 p.

Mimicking the Articular Joint with In Vitro Models

Piluso Susanna, Li Yang, Abinzano Florencia, Levato Riccardo, Moreira Teixeira Liliana, Karperien Marcel, Leijten Jeroen, van Weeren René, Malda Jos 16 apr 2019, In: Trends in biotechnology. 37 , p. 1063-1077 15 p.

All Research Output (134)
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