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dr. J.H.W. (Jeanette) Leusen Associate Professor

  • Laboratory for Translational Immunology (LTI)

J.H.W. Leusen

Contact

Research Programs

Biography

Dr. Jeanette Leusen, received her PhD in 1995 at the University of Amsterdam, The Netherlands. She became associate professor and head of the immunotherapy group of the University Medical Center in Utrecht in 2006, and head of the UMAB facility in 2012. She has co-authored more than 100 publications in peer-reviewed journals on the working mechanisms of therapeutic antibodies, but also on IgA as a novel class of antibody for the treatment of both malignant as infectious disease.

Side Activities

  • Dr Leusen is the scientific founder of TigaTx.

    Dr Leusen is senior editor of several Immunology/cancer journals and was organizer of the FASEB meeting on Immunoreceptors of 2014 and 2016, and was vice chair of the Gordon Research Conference on antibodies in 2018, and main chair in 2020

Fellowship and Awards

  • Dr Leusen holds several grants from NWO (STW), KWF, KiKa, Villa Joep! and industry.

Research Output (96)

Identification of a tumor-specific allo-HLA-restricted γδTCR

Kierkels G J J, Scheper W, Meringa A D, Johanna I, Beringer D X, Janssen A, Schiffler M, Aarts-Riemens T, Kramer L, Straetemans T, Heijhuurs S, Leusen J H W, San José E, Fuchs K, Griffioen M, Falkenburg J H, Bongiovanni L, de Bruin A, Vargas-Diaz D, Altelaar M, Heck A J R, Shultz L D, Ishikawa F, Nishimura M I, Sebestyén Z, Kuball J 8 okt 2019, In: Blood Advances. 3 , p. 2870-2882 13 p.

Functional diversification of hybridoma-produced antibodies by CRISPR/HDR genomic engineering

van der Schoot Johan M S, Fennemann Felix L, Valente Michael, Dolen Yusuf, Hagemans Iris M, Becker Anouk M D, Le Gall Camille M, van Dalen Duco, Cevirgel Alper, van Bruggen Jaco A C, Engelfriet Melanie, Caval Tomislav, Bentlage Arthur E H, Fransen Marieke F, Nederend Maaike, Leusen Jeanette H W, Heck Albert J R, Vidarsson Gestur, Figdor Carl G, Verdoes Martijn, Scheeren Ferenc A 28 aug 2019, In: Science advances. 5 12 p.

Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy

Logtenberg Meike E W, Jansen J H Marco, Raaben Matthijs, Toebes Mireille, Franke Katka, Brandsma Arianne M, Matlung Hanke L, Fauster Astrid, Gomez-Eerland Raquel, Bakker Noor A M, van der Schot Simone, Marijt Koen A, Verdoes Martijn, Haanen John B A G, van den Berg Joost H, Neefjes Jacques, van den Berg Timo K, Brummelkamp Thijn R, Leusen Jeanette H W, Scheeren Ferenc A, Schumacher Ton N apr 2019, In: Nature Medicine. 25 , p. 612-619 8 p.

CD123 expression levels in 846 acute leukemia patients based on standardized immunophenotyping

Bras Anne E, de Haas Valerie, van Stigt Arthur, Jongen-Lavrencic Mojca, Beverloo H Berna, Te Marvelde Jeroen G, Zwaan C Michel, van Dongen Jacques J M, Leusen Jeanette H W, van der Velden Vincent H J 1 mrt 2019, In: Cytometry. Part B, Clinical Cytometry.. 96 , p. 134-142 9 p.

CD47 Blockade and Rituximab in Non-Hodgkin’s Lymphoma

Valerius Thomas, Rösner Thies, Leusen Jeanette H W 31 jan 2019, In: The New England journal of medicine. 380 , p. 496-497 2 p.

Potent Fc Receptor Signaling by IgA Leads to Superior Killing of Cancer Cells by Neutrophils Compared to IgG

Brandsma Arianne M, Bondza Sina, Evers Mitchell, Koutstaal Rosanne, Nederend Maaike, Jansen J H Marco, Rösner Thies, Valerius Thomas, Leusen Jeanette H W, Ten Broeke Toine 1 jan 2019, In: Frontiers in Immunology. 10

Immune Effector Functions of Human IgG2 Antibodies against EGFR

Rösner Thies, Kahle Steffen, Montenegro Francesca, Matlung Hanke L, Jansen J H Marco, Evers Mitchell, Beurskens Frank, Leusen Jeanette H W, van den Berg Timo K, Valerius Thomas jan 2019, In: MOLECULAR CANCER THERAPEUTICS. 18 , p. 75-88 14 p.

Breast Milk Prefusion F Immunoglobulin G as a Correlate of Protection Against Respiratory Syncytial Virus Acute Respiratory Illness

Mazur Natalie I., Horsley Nicole M., Englund Janet A., Nederend Maaike, Magaret Amalia, Kumar Azad, Jacobino Shamir R., de Haan Cornelis A.M., Khatry Subarna K., LeClerq Steven C., Steinhoff Mark C., Tielsch James M., Katz Joanne, Graham Barney S., Bont Louis J., Leusen Jeanette H.W., Chu Helen Y. 10 aug 2018, In: Journal of Infectious Diseases. 219 , p. 59-67 9 p.

Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis

Matlung Hanke L., Babes Liane, Zhao Xi Wen, van Houdt Michel, Treffers Louise W., van Rees Dieke J., Franke Katka, Schornagel Karin, Verkuijlen Paul, Janssen Hans, Halonen Pasi, Lieftink Cor, Beijersbergen Roderick L., Leusen Jeanette H.W., Boelens Jaap J., Kuhnle Ingrid, van der Werff Ten Bosch Jutte, Seeger Karl, Rutella Sergio, Pagliara Daria, Matozaki Takashi, Suzuki Eiji, Menke-van der Houven van Oordt Catharina Willemien, van Bruggen Robin, Roos Dirk, van Lier Rene A.W., Kuijpers Taco W., Kubes Paul, van den Berg Timo K. 26 jun 2018, In: Cell Reports. 23 , p. 3946-3959.e6

Effector mechanisms of IgA antibodies against CD20 include recruitment of myeloid cells for antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity

Lohse Stefan, Loew Sebastian, Kretschmer Anna, Jansen J H Marco, Meyer Saskia, Ten Broeke Toine, Rösner Thies, Dechant Michael, Derer Stefanie, Klausz Katja, Kellner Christian, Schwanbeck Ralf, French Ruth R, Tipton Thomas R W, Cragg Mark S, Schewe Denis M, Peipp Matthias, Leusen Jeanette H W, Valerius Thomas mei 2018, In: British Journal of Haematology. 181 , p. 413-417

All Research Output (96)
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