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dr. dr.h.c.mult A.L.G. (Alexander) Leemans Associate Professor

  • Image Sciences Institute

A.L.G. Leemans


Research Programs


Alexander Leemans is a physicist who received his Ph.D. in 2006 at the University of Antwerp, Belgium. From 2007 to 2009, he worked as a postdoctoral researcher at the Cardiff University Brain Research Imaging Center (CUBRIC), Cardiff University, Wales, United Kingdom. In 2009, he joined the Image Sciences Institute (ISI), University Medical Center Utrecht, the Netherlands, where he currently holds a tenured faculty position as Associate Professor. His current research interests include modeling, processing, visualizing and analyzing diffusion MRI data for investigating microstructural and architectural tissue organization. He heads the PROVIDI Lab and is the developer of ExploreDTI, which is a graphical toolbox for investigating diffusion MRI data.

Research line

Diffusion MRI

Most recent key publications

1: C. Lebel, L. Walker, A. Leemans, L. Phillips, C. Beaulieu, "Microstructural Maturation of the Human Brain from Childhood to Adulthood", NeuroImage, 2008, nr. 3, vol. 40, pp. 1044-1055
2: A. Leemans, D.K. Jones, "The B-matrix must be rotated when correcting for subject motion in DTI data", Magnetic Resonance in Medicine, 2009, nr. 1, vol. 62, pp. 1336-1349
3: J.D. Tournier, S. Mori, A. Leemans, "Diffusion tensor imaging and beyond", Magnetic Resonance in Medicine, 2011, nr. 6, vol. 65, pp. 1532-1556
4: B. Jeurissen, A. Leemans, J.D. Tournier, D.K. Jones, J. Sijbers, "Investigating the prevalence of complex fiber configurations in white matter tissue with diffusion MRI", Human Brain Mapping, 2013, nr. 11, vol. 34, pp. 2747-2766
5: S.B. Vos, D.K. Jones, M.A. Viergever, A. Leemans, "Partial volume effect as a hidden covariate in DTI analyses", NeuroImage, 2011, nr. 4, vol. 55, pp. 1566-1576

Fellowship and Awards

  • VIDI (NWO)

    FC-EW (NWO)


    PhD fellowship (IWT)

    Honorary Doctorate (Chubut)

    Young Investigator Award (BHPA)

    Outstanding Teacher Award (ISMRM)

Research Output (209)

Tractography reproducibility challenge with empirical data (TraCED):The 2017 ISMRM diffusion study group challenge

Nath Vishwesh, Schilling Kurt G., Parvathaneni Prasanna, Huo Yuankai, Blaber Justin A., Hainline Allison E., Barakovic Muhamed, Romascano David, Rafael-Patino Jonathan, Frigo Matteo, Girard Gabriel, Thiran Jean Philippe, Daducci Alessandro, Rowe Matt, Rodrigues Paulo, Prčkovska Vesna, Aydogan Dogu B., Sun Wei, Shi Yonggang, Parker William A., Ould Ismail Abdol A., Verma Ragini, Cabeen Ryan P., Toga Arthur W., Newton Allen T., Wasserthal Jakob, Neher Peter, Maier-Hein Klaus, Savini Giovanni, Palesi Fulvia, Kaden Enrico, Wu Ye, He Jianzhong, Feng Yuanjing, Paquette Michael, Rheault Francois, Sidhu Jasmeen, Lebel Catherine, Leemans Alexander, Descoteaux Maxime, Dyrby Tim B., Kang Hakmook, Landman Bennett A. 1 jan 2020, In: Journal of Magnetic Resonance Imaging. 51 , p. 234-249 16 p.

On the sensitivity of the diffusion MRI signal to brain activity in response to a motor cortex paradigm

De Luca Alberto, Schlaffke Lara, Siero Jeroen C.W., Froeling Martijn, Leemans Alexander 1 dec 2019, In: Human Brain Mapping. 40 , p. 5069-5082 14 p.

Reducing variability in along-tract analysis with diffusion profile realignment

St-Jean S, Chamberland Maxime, Leemans Alexander, Viergever MA 1 okt 2019, In: NeuroImage. 199 , p. 663-679 17 p.

Magnetic resonance imaging of the cervical spinal cord in spinal muscular atrophy

Stam Marloes, Haakma Wieke, Kuster Lidy, Froeling Martijn, Philippens Marielle E P, Bos Clemens, Leemans Alexander, Otto Louise A M, van den Berg Leonard H, Hendrikse Jeroen, van der Pol W Ludo 3 sep 2019, In: Neuroimage: Clinical [E]. 24 9 p.

Physical Performance in Memory Clinic Patients:The Potential Role of the White Matter Network

Verwer Jurre H., Reijmer Yael D., Koek H. L., Biessels Geert Jan, Exalto L. G., Groeneveld O. N., Heinen R., Heringa S. M., Kalsbeek N., Maher C., de Bresser J., Leemans A., Koek H. L., de Wit J. E., Blom K., Hamaker M., Faaij R., Pleizier M., Prins M., Vriens E., 1 sep 2019, In: Journal of the American Geriatrics Society. 67 , p. 1880-1887 8 p.

Any Radiation Dose to the Hippocampus Leads to Local Volume Loss in a Dose-Time-Dependent Way

Nagtegaal S., David S., Philippens M., Leemans A., Verhoeff J. 1 sep 2019, In: International Journal of Radiation Oncology Biology Physics. 105 , p. E104-E105

The adverse effect of gradient nonlinearities on diffusion MRI:From voxels to group studies

Mesri Hamed Y., David Szabolcs, Viergever Max A., Leemans Alexander 30 aug 2019, In: NeuroImage. 205 15 p.

Evaluation of the 3D fractal dimension as a marker of structural brain complexity in multiple-acquisition MRI

Krohn Stephan, Froeling Martijn, Leemans Alexander, Ostwald Dirk, Villoslada Pablo, Finke Carsten, Esteban Francisco J. 1 aug 2019, In: Human Brain Mapping. 40 , p. 3299-3320 22 p.

Cross-scanner and cross-protocol diffusion MRI data harmonisation:A benchmark database and evaluation of algorithms

Tax Chantal Mw, Grussu Francesco, Kaden Enrico, Ning Lipeng, Rudrapatna Umesh, Evans John, St-Jean Samuel, Leemans Alexander, Koppers Simon, Merhof Dorit, Ghosh Aurobrata, Tanno Ryutaro, Alexander Daniel C, Zappalà Stefano, Charron Cyril, Kusmia Slawomir, Linden David Ej, Jones Derek K, Veraart Jelle 15 jul 2019, In: NeuroImage. 195 , p. 285-299

Changes in cortical thickness and volume after cranial radiation treatment:A systematic review

Nagtegaal Steven H.J., David Szabolcs, van der Boog Arthur T.J., Leemans Alexander, Verhoeff Joost J.C. 1 jun 2019, In: Radiotherapy and Oncology. 135 , p. 33-42 10 p.

All Research Output (209)
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