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prof. dr. L.S. (Linda) de Vries Full Professor

  • Birth Center Neonatology - Medical

L.S. de Vries

Contact

Biography

Linda de Vries obtained her PhD degree in Utrecht (1987) with Leo van de Brande. The degree was based on data collected during a 4 year research period at the Hammersmith Postgraduate school in London where she worked with Lilly and Victor Dubowitz in the field of Neonatal Neurology. Between 1987 and 1989 she did her Pediatric Neurology fellowship in Leuven with Paul Casaer. Since 1989, she has worked in the department of Neonatology in Utrecht, where she is a professor in Neonatal Neurology since 2001.

Her research focuses on prediction of neurodevelopmental outcome in high risk preterm and full-term newborns, using neurophysiology and neuro-imaging methods.  These at risk children are also seen by her in the follow-up clinic until early childhood. She has a special interest in neonatal stroke and brain plasticity.  Her work has been published in >300 publications.

 

Research line

Neonatal Neurology

Most recent key publications

1: van de Aa NE, Benders MJNL, Vincken KL,Groenendaal F, de Vries LS, The course of apparent diffusion coefficient values following perinatal arterial ischemic stroke. PlosOne 2013;8(2):e56784
2: Haastert IC, Groenendaal F, Uiterwaal CSPM, Termote JUM, van der Heide-Jalving M, Eijsermans MJC, Gorter JW, Helders PJM, Jongmans MJ, de Vries LS. Decreasing incidence and severity of cerebral palsy in prematurely born children. J Pediatr 2011; 159:8
3: Van Rooij, LGM, Toet, MC , van Huffelen AC, Groenendaal F, Laan W, Zezic A, de Haan T, van Straaten ILM, Vrancken S, van Wezel G, van der Sluijs J, ter Horst H, Gavilanes D, Laroche S, Naulaers G, de Vries LS. Effect of treatment of subclinical neonatal seizures detected with continuous amplitude-integrated electroencephalographic monitoring: a randomised controlled Trial. Pediatrics. 2010;125:e358-66
4: de Vries LS, Koopman C, Groenendaal F, van Schooneveld M, Verheijen F, Verbeek E, WitkampTh D, van der Worp HB, Mancini GMS. COL4A1 mutation in two preterm siblings with antenatal onset of parenchymal hemorrhage. Annals Neurol 2009; 65:12-18
5: Pressler RM, Boylan GB, Marlow N, Blennow M, Chiron C, Cross JH, de Vries LS, Hallberg B, Hellström-Westas L, Jullien V, Livingstone V, Mangum B, Murphy B, Murray D, Pons G, Rennie J, Swarte R, Toet MC, Vanhatalo S, Zohar S, for the NEonatal seizure treatment with Medication Off -patent (NEMO)consortium Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial. Lancet Neurology 2015 Mar 9. pii: S1474-4422(14)70303-5

Fellowship and Awards

  • 1: Honorary award of the German speaking society of Neuropediatrics (GNP) 2015
    2: ZonMW, co-applicant, Adult mesenchymal stem cells (MSC) to regenerate the neonatal brain (2011)
    3: EU-FP7, co-applicant, NEMO1: An open label exploratory dose finding and pharmacokinetic clinical trial of bumetanide for the treatment of NEonatal seizure using Medication Off-patent. (2010)
    4: Harwood Nash memorial lecture, Toronto, 2012
    5: McCance Lecture (British Neonatal Society), 2004
    6: Bruce Berg Visiting Professor Lecture (UCSF San Francisco), 2004

Research Output (600)

TMX2 Is a Crucial Regulator of Cellular Redox State, and Its Dysfunction Causes Severe Brain Developmental Abnormalities

Vandervore Laura V, Schot Rachel, Milanese Chiara, Smits Daphne J, Kasteleijn Esmee, Fry Andrew E, Pilz Daniela T, Brock Stefanie, Börklü-Yücel Esra, Post Marco, Bahi-Buisson Nadia, Sánchez-Soler María José, van Slegtenhorst Marjon, Keren Boris, Afenjar Alexandra, Coury Stephanie A, Tan Wen-Hann, Oegema Renske, de Vries Linda S, Fawcett Katherine A, Nikkels Peter G J, Bertoli-Avella Aida, Al Hashem Amal, Alwabel Abdulmalik A, Tlili-Graiess Kalthoum, Efthymiou Stephanie, Zafar Faisal, Rana Nuzhat, Bibi Farah, Houlden Henry, Maroofian Reza, Person Richard E, Crunk Amy, Savatt Juliann M, Turner Lisbeth, Doosti Mohammad, Karimiani Ehsan Ghayoor, Saadi Nebal Waill, Akhondian Javad, Lequin Maarten H, Kayserili Hülya, van der Spek Peter J, Jansen Anna C, Kros Johan M, Verdijk Robert M, Milošević Nataša Jovanov, Fornerod Maarten, Mastroberardino Pier Giorgio, Mancini Grazia M S 5 dec 2019, In: American Journal of Human Genetics. 105 , p. 1126-1147 22 p.

Viral Infections and the Neonatal Brain

de Vries Linda S. 1 dec 2019, In: Seminars in Pediatric Neurology. 32

Signal Change in the Mammillary Bodies after Perinatal Asphyxia

Molavi M, Vann S D, de Vries L S, Groenendaal F, Lequin M 6 nov 2019, In: American Journal of Neuroradiology. 40 , p. 1829-1834 6 p.

Periventricular Hemorrhagic Infarction in Very Preterm Infants:Characteristic Sonographic Findings and Association with Neurodevelopmental Outcome at Age 2 Years

Cizmeci Mehmet N, de Vries Linda S, Ly Linh G, van Haastert Ingrid C, Groenendaal Floris, Kelly Edmond N, Traubici Jeffrey, Whyte Hilary E, Leijser Lara M 6 nov 2019, In: The Journal of Pediatrics. 217 , p. 79-85.e1

Heterozygous Variants in the Mechanosensitive Ion Channel TMEM63A Result in Transient Hypomyelination during Infancy

Yan Huifang, Helman Guy, Murthy Swetha E, Ji Haoran, Crawford Joanna, Kubisiak Thomas, Bent Stephen J, Xiao Jiangxi, Taft Ryan J, Coombs Adam, Wu Ye, Pop Ana, Li Dongxiao, de Vries Linda S, Jiang Yuwu, Salomons Gajja S, van der Knaap Marjo S, Patapoutian Ardem, Simons Cas, Burmeister Margit, Wang Jingmin, Wolf Nicole I 27 sep 2019, In: American Journal of Human Genetics. 105 , p. 996-1004 9 p.

Brain Injury in Infants with Critical Congenital Heart Disease:Insights from Two Clinical Cohorts with Different Practice Approaches

Claessens Nathalie H P, Chau Vann, de Vries Linda S, Jansen Nicolaas J G, Au-Young Stephanie H, Stegeman Raymond, Blaser Susan, Shroff Manohar, Haas Felix, Marini Davide, Breur Johannes M P J, Seed Mike, Benders Manon J N L, Miller Steven P 23 aug 2019, In: The Journal of Pediatrics. 215 , p. 75-82.e2

Brain Activity and Cerebral Oxygenation After Perinatal Arterial Ischemic Stroke Are Associated With Neurodevelopment

Wagenaar Nienke, van den Berk Daphne J. M., Lemmers Petra M. A., van der Aa Niek E., Dudink Jeroen, van Bel Frank, Groenendaal Floris, de Vries Linda S., Benders Manon J. N. L., Alderliesten Thomas 8 aug 2019, In: Stroke. 50 , p. 2668-2676 9 p.

Early prediction of unilateral cerebral palsy in infants with asymmetric perinatal brain injury – Model development and internal validation

Ryll Ulrike C., Wagenaar Nienke, Verhage Cornelia H., Blennow Mats, de Vries Linda S., Eliasson Ann Christin 1 jul 2019, In: European Journal of Paediatric Neurology. 23 , p. 621-628 8 p.

Preface:Neonatal Neurology

de Vries Linda S, Glass Hannah C jul 2019, In: Handbook of Clinical Neurology. 162 , p. ix

The CHOPIn Study:a Multicenter Study on Cerebellar Hemorrhage and Outcome in Preterm Infants

Boswinkel V., Steggerda S. J., Fumagalli M., Parodi A., Ramenghi L. A., Groenendaal F., Dudink J., Benders M. N., Knol R., de Vries L. S., van Wezel-Meijler G. 27 jun 2019, In: Cerebellum (London, England). 18 , p. 989-998 10 p.

All Research Output (600)
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